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Invitrogen™ RNF128 Polyclonal Antibody
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Catalog No. PIPA554054
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100 μL
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PIPA554054 100 μL
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Catalog No. PIPA554054 Supplier Invitrogen™ Supplier No. PA554054
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: HKTCVDPWLL EHRTCPMCKC DILKALGIEV DVEDGSVSLQ VPVSNEISNS ASSHEEDNRS ETASSGYASV QGTDEPPLEE HVQSTNESLQ LVNHEANSVA VDVIPHVDNP TFEEDETPNQ ETA Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 92%.

GRAIL is a type I transmembrane protein that localizes to the endocytic pathway and contains a PA (protease associated) domain and a RING-type zinc finger domain. It is a ubiquitin-protein isopeptide ligase (E3) necessary for the induction of CD4(+) T cell anergy in vivo and induced expression of this protein was observed in anergic CD4 (+) T cells, which suggested a role in the induction of anergic phenotype. It is differentially expressed in naturally occurring and peripherally induced CD25 (+) T regulatory cells and the expression is linked to the conversion of these cells to a regulatory phenotype. Expression of GRAIL in retrovirally transduced T cell hybridomas limits activation-induced IL-2 and IL-4 cytokine production. It also functions in the patterning of the dorsal ectoderm and sensitizes ectoderm to respond to neural-inducing signals.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RNF128
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene RNF128
Gene Accession No. Q8TEB7
Gene Alias 1300002C13Rik; AI987883; E3 ubiquitin-protein ligase RNF128; Gene related to anergy in lymphocytes protein; goliath-related E3 ubiquitin-protein ligase 1; Grail; Greul1; MNCb-3816; RGD1566282; RING finger protein 128; ring finger protein 128, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF128; RNF128; RP11-150F24.1
Gene Symbols RNF128
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human RNF128. Recombinant protein control fragment (Product #RP-92127).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79589
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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