Invitrogen™ RNF144B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA562927

Catalog No. PIPA562927

Description

Immunogen sequence: MGSAGRLHYL AMTAENPTPG DLAPAPLITC KLCLCEQSLD KMTTLQECQC IF Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 77%.

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.

Specifications

• Antigen: RNF144B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RNF144B
• Gene Alias: bA528A10.3; BC025007; E130105P19Rik; E3 ubiquitin-protein ligase RNF144B; IBR domain containing 2; IBR domain-containing protein 2; IBRDC2; p53-inducible RING finger protein; p53RFP; PIR2; RING finger protein 144B; Rnf144b
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 255488
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.5 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q7Z419
• Gene Symbols: RNF144B
• Immunogen: Recombinant protein corresponding to Human RNF144B. Recombinant protein control fragment (Product #RP-103175).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov