RNF144B Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA589387

Catalog No. PIPA589387

Description

Immunogen sequence: MGSAGRLHYL AMTAENPTPG DLAPAPLITC KLCLCEQSLD KMTTLQECQC IFCTACLKQY MQLAIREGCG SPITCPDMVC LNHGTLQEAE IACLVPVDQF QLYQRLKFER EVHLDPYRTW CPVADCQTVC PVASSDPGQP VLVECPSCHL KFCSCCKDAW HAEVSCRDSQ PIVLPTEHRA LFGTDAEAPI KQCPVCRVYI; Positive Samples: Mouse kidney, Rat liver, ; Cellular Location: Cytoplasm, Mitochondrion membrane, Single-pass membrane protein

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, μgtimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.

Specifications

• Antigen: RNF144B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RNF144B
• Gene Alias: bA528A10.3, BC025007, E130105P19Rik, E3 ubiquitin-protein ligase RNF144B, IBR domain containing 2, IBR domain-containing protein 2, IBRDC2, p53-inducible RING finger protein, p53RFP, PIR2, RING finger protein 144B, Rnf144b
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 218215, 364681
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 1.87 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
• Gene Accession No.: Q8BKD6
• Gene Symbols: RNF144B
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human RNF144B (NP_8774342)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov