Invitrogen™ RNF157 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA554529

Catalog No. PIPA554529

Description

Immunogen sequence: EEEDGSPTQE GQRTCAFLGM ECDNNNDFDI ASVKALDNKL CSEVCLPGAW QADDNAVSRN AQ Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 78%.

E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469). May act as a scaffold molecule to regulate this process (PubMed:25342469). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764). [UniProt].

Specifications

• Antigen: RNF157
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RNF157
• Gene Alias: 2610036E23Rik; A130073L17Rik; E3 ubiquitin ligase RNF157; KIAA1917; mKIAA1917; ring finger protein 157; RING-type E3 ubiquitin transferase RNF157; RNF157
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114804
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96PX1
• Gene Symbols: RNF157
• Immunogen: Recombinant protein corresponding to Human RNF157. Recombinant protein control fragment (Product #RP-93307).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG