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Invitrogen™ RNF168 Polyclonal Antibody
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Catalog No. PIPA531119
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100 μL
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Catalog No. Quantity
PIPA531119 100 μL
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Catalog No. PIPA531119 Supplier Invitrogen™ Supplier No. PA531119
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: PC-3, human RNF168-transfected 293T. Predicted reactivity: Chimpanzee (98%), Bovine (84%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

RNF168 was identified as a chromatin-associated RING finger protein that acts as a ubiquitin ligase both in vitro and in vivo. RNF168 targets histones H2A and H2AX, but not H2B, forming K63 polyubiquitin chains. Upon formation of DNA double strand breaks, RNF168 is recruited to the site of DNA damage where it co-localizes with -gammaH2AX and 53BP1 in an RNF8-dependent manner. This localization of RNF168 increases the local concentration of ubiquinated proteins to the threshold required for retention of the proteins 53BP1 and BRCA1, facilitating the downstream signaling cascade. Thus, RNF168 defines a new pathway demonstrating a functional cooperation between E3 ligases in genome maintenance. At least three isoforms of RNF168 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RNF168
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene RNF168
Gene Accession No. Q8IYW5
Gene Alias 3110001H15Rik; E3 ubiquitin-protein ligase RNF168; FLJ35794; hRNF168; RING finger protein 168; ring finger protein 168, E3 ubiquitin protein ligase; ring fnger protein 168; RING-type E3 ubiquitin transferase RNF168; RNF168
Gene Symbols RNF168
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human RNF168. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 165918
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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