Invitrogen™ RNF169 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA566164

Catalog No. PIPA566164

Description

Immunogen sequence: KAKVTTMTPAS NPIIGVLLST QNNRCVSAPD LTIEKRLPFS SLSSLASLHK PERSVSPESN DSISEELNHF KPIVCSPCTP PKRLPDGRVL SPLIIKSTPR NLN Highest antigen sequence identity to the following orthologs - mouse 91%, rat 91%.

Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.

Specifications

• Antigen: RNF169
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RNF169
• Gene Alias: 2900057K09Rik; E3 ubiquitin-protein ligase RNF169; KIAA1991; RING finger protein 169; RING finger protein 169; E3 ubiquitin-protein ligase RNF169; RING-type E3 ubiquitin transferase RNF169; RNF169
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 254225
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8NCN4
• Gene Symbols: RNF169
• Immunogen: Recombinant Human RNF169. Recombinant protein control fragment (Product #RP-106847).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov