Invitrogen™ RNF169 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5114398

Catalog No. PIPA5114398

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human U20S whole cell, human K562 whole cell. IHC: human colon cancer tissue, human mammary cancer tissue, mouse small intestine tissue, rat small intestine tissue. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.

Specifications

• Antigen: RNF169
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RNF169
• Gene Alias: 2900057K09Rik; E3 ubiquitin-protein ligase RNF169; KIAA1991; RING finger protein 169; RING finger protein 169; E3 ubiquitin-protein ligase RNF169; RING-type E3 ubiquitin transferase RNF169; RNF169
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 108937, 254225, 685009
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and 0.05mg sodium azide
• Gene Accession No.: E9Q7F2, Q8NCN4
• Gene Symbols: RNF169
• Immunogen: E.coli-derived human RNF169 recombinant protein (Position: N311-K708).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG