Invitrogen™ RNF183 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA563466

Catalog No. PIPA563466

Description

Immunogen sequence: ELEAECPVCW NPFNNTFHTP KMLDCCHSFC VECLAHLSLV TPARRRLLCP LCRQPTVLAS GQPVTDLPTD Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 94%.

Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29507230). Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (PubMed:29507230). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849). [UniProt].

Specifications

• Antigen: RNF183
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RNF183
• Gene Alias: 5830442J12Rik; E3 ubiquitin-protein ligase RNF183; ring finger protein 183; Rnf183
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 138065
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96D59
• Gene Symbols: RNF183
• Immunogen: Recombinant protein corresponding to Human RNF183. Recombinant protein control fragment (Product #RP-99866).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov