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Invitrogen™ RNF183 Polyclonal Antibody
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Catalog No. PIPA563466
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100 μL
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Catalog No. Quantity
PIPA563466 100 μL
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Catalog No. PIPA563466 Supplier Invitrogen™ Supplier No. PA563466
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ELEAECPVCW NPFNNTFHTP KMLDCCHSFC VECLAHLSLV TPARRRLLCP LCRQPTVLAS GQPVTDLPTD Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 94%.

Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29507230). Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (PubMed:29507230). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen RNF183
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene RNF183
Gene Accession No. Q96D59
Gene Alias 5830442J12Rik; E3 ubiquitin-protein ligase RNF183; ring finger protein 183; Rnf183
Gene Symbols RNF183
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human RNF183. Recombinant protein control fragment (Product #RP-99866).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 138065
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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