Invitrogen™ RNF185 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5107016

Catalog No. PIPA5107016

Description

Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 92%; Rat: 100%; Zebrafish: 100%.

RNF185 is a E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating Lys-63-linked polyubiquitination of BNIP1. RNF185 acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. RNF185 protects cells from ER stress-induced apoptosis. is responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway, and is preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.

Specifications

• Antigen: RNF185
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RNF185
• Gene Alias: BSK65-MONO1; BSK65-MONO2; BSK65-PANC1; BSK65-PANC2; BSK65-TEST1; BSK65-TEST2; BSK65-TEST3; E3 ubiquitin-protein ligase RNF185; FLJ38628; I79_017427; ring finger protein 185; RING-type E3 ubiquitin transferase RNF185; rn185; Rnf185
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 91445
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q96GF1
• Gene Symbols: RNF185
• Immunogen: Synthetic peptide directed towards the middle region of human RNF185 (aa 74-124).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov