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Invitrogen™ RNF185 Polyclonal Antibody
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Catalog No. PIPA5116662
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100 μL
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PIPA5116662 100 μL
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Catalog No. PIPA5116662 Supplier Invitrogen™ Supplier No. PA5116662
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Description

Rabbit Polyclonal Antibody

Positive Samples: Mouse testis Immunogen sequence: MASKGPSASA SPENSSAGGP SGSSNGAGES GGQDSTFECN ICLDTAKDAV ISLCGHLFCW PCLHQWLETR PNRQVCPVCK AGISRDKVIP LYGRGSTGQQ DPREKTPPRP QGQRPEPENR GGFQGFGFGD.

RNF185 is a E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating Lys-63-linked polyubiquitination of BNIP1. RNF185 acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. RNF185 protects cells from ER stress-induced apoptosis. is responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway, and is preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RNF185
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.33 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene RNF185
Gene Accession No. Q568Y3, Q91YT2, Q96GF1
Gene Alias BSK65-MONO1; BSK65-MONO2; BSK65-PANC1; BSK65-PANC2; BSK65-TEST1; BSK65-TEST2; BSK65-TEST3; E3 ubiquitin-protein ligase RNF185; FLJ38628; I79_017427; ring finger protein 185; RING-type E3 ubiquitin transferase RNF185; rn185; Rnf185
Gene Symbols RNF185
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human RNF185 (NP_6894802).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 193670, 360967, 91445
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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