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Invitrogen™ RNF2 Polyclonal Antibody
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Catalog No. PIPA582935
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100 μL
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PIPA582935 100 μL
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Catalog No. PIPA582935 Supplier Invitrogen™ Supplier No. PA582935
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ALISKIYPSR DEYEAHQERV LARINKHNNQ QALSHSIEEG LKIQAMNRLQ RGKKQQIENG SGAEDNGDSS HCSNASTHSN QEAGPSNKRT KTSDDSGLEL DNNNAAMAID PVMDGASEIE LV Highest antigen sequence indentity to the following orthologs: Rat - 99%, Mouse - 99%.

RNF2 (E3 ubiquitin-protein ligase RING2) is a ligase that mediates monoubiquitination of Lys-119 of histone H2A (H2AK119Ub). Therefore, it plays a central role in histone code and gene regulation. The ligase activity is enhanced by BMI1/PCGF4. H2AK119Ub gives a specific tag for epigeneti transcriptional repression and participates in X chromosome inactivation of female mammals. RNF2 may be involved in the initiation of both imprinted and random X inactivation. RNF2 is also an essential component of a Polycomb group (PcG) multiprotein PRC1-like complex. This complex class is required to maintain the transcriptionally repressive state of many genes including Hox genes throughout development. The PcG PRC1 complex acts via chromatin remodeling and modification of histones and rendering chromatin heritably changed in its expressibility.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RNF2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene RNF2
Gene Accession No. Q99496
Gene Alias AI326319; AI450156; AU019207; BAP 1; BAP1; BAP-1; DinG; DinG protein; E3 ubiquitin-protein ligase RING2; fa19h05; GS1-120K12.1; HIP2-interacting protein 3; HIPI 3; HIPI3; Huntingtin-interacting protein 2-interacting protein 3; OTTHUMP00000060668; protein DinG; RING 1B; RING 2; RING finger protein 1B; ring finger protein 2; RING finger protein BAP-1; RING1B; RING2; RING-type E3 ubiquitin transferase RING2; RNF 2; Rnf2; wu:fa19h05; wz4556; wz4566
Gene Symbols RNF2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human RNF2. Recombinant protein control fragment (Product #RP-89475).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6045
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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