Invitrogen™ RNF20 Monoclonal Antibody (1C6)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA522274

Catalog No. PIMA522274

Description

Peptide Sequence: RVESSRRAVS QIVTVYDKLQ EKVELLSRKL NSGDNLIVEE AVQELNSFLA QENMRLQELT DLLQEKHRTM SQEFSKLQSK VETAESRVSV LESMIDDLQW.

RNF20 is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. RNF20 selectively suppresses the expression of some genes such as several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). In contrast, RNF20 also positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. Together with the deubiquitinase USP44, RNF20 regulates stem cell differentiation by modulating H2B monoubiquitination.

Specifications

• Antigen: RNF20
• Classification: Monoclonal
• Concentration: 0.2-1.0 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q5VTR2
• Gene Symbols: RNF20
• Immunogen: RNF20 (NP_062538, 177 a.a. ~ 276 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA, Western Blot
• Clone: 1C6
• Conjugate: Unconjugated
• Gene: RNF20
• Gene Alias: 4833430L21Rik; AW540162; BRE1; BRE1 E3 ubiquitin ligase homolog; BRE1A; BRE1-A; C79397; E3 ubiquitin-protein ligase BRE1A; FLJ11189; FLJ20382; hBRE1; HNF3B; homolog of S. cerevisiae BRE1; hypothetical protein; KIAA2779; Kiaa4116; MGC129667; MGC129668; mKIAA4116; RCJMB04_5a23; RING finger protein 20; ring finger protein 20, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase BRE1A; Rnf20; TCF3B
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 56254
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid