RNF20 Mouse anti-Human, Clone: OTI13A10, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF807609

Catalog No. 50-166-8367

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

RNF20 is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. RNF20 selectively suppresses the expression of some genes such as several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). In contrast, RNF20 also positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. Together with the deubiquitinase USP44, RNF20 regulates stem cell differentiation by modulating H2B monoubiquitination.

Specifications

• Antigen: RNF20
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: RNF20
• Gene Alias: BRE1, BRE1A, hBRE1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 56254
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI13A10
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q5VTR2
• Gene Symbols: RNF20
• Immunogen: Human recombit protein fragment corresponding to amino acids 493-754 of human RNF20 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1