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RNF20 Mouse anti-Human, Clone: OTI2B9, lyophilized, TrueMAB™
SDP

Catalog No. 501668368
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100 μg
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50-166-8368 100 μg
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Catalog No. 50-166-8368 Supplier OriGene Supplier No. CF807610
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Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

RNF20 is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. RNF20 selectively suppresses the expression of some genes such as several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). In contrast, RNF20 also positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. Together with the deubiquitinase USP44, RNF20 regulates stem cell differentiation by modulating H2B monoubiquitination.

Specifications

Antigen RNF20
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI2B9
Conjugate Unconjugated
Formulation PBS with 8% trehalose and no preservative; pH 7.3
Gene RNF20
Gene Accession No. Q5VTR2
Gene Alias BRE1, BRE1A, hBRE1
Gene Symbols RNF20
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 493-754 of human RNF20 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56254
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2b
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