RNF20 Rabbit anti-Human, Mouse, Polyclonal, Bethyl Laboratories

Catalog No.	Quantity
50-155-8286	100 μL

Catalog No. 50-155-8286

Supplier: Bethyl Laboratories, Inc A300715A

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predicted to react with Chicken and Bovine

RNF20 is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. RNF20 selectively suppresses the expression of some genes such as several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). In contrast, RNF20 also positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. Together with the deubiquitinase USP44, RNF20 regulates stem cell differentiation by modulating H2B monoubiquitination.

Specifications

• Antigen: RNF20
• Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/ml
• Conjugate: Unconjugated
• Formulation: phosphate, tris citrate with 0.09% sodium azide; pH 7-8
• Gene: RNF20
• Gene Accession No.: Q5DTM8, Q5VTR2
• Gene Alias: BRE1, BRE1A, FLJ11189, FLJ20382, KIAA2779, MGC129667, MGC129668, hBRE1, BRE1 E3 ubiquitin ligase homolog; BRE1-A; E3 ubiquitin-protein ligase BRE1A; homolog of S. cerevisiae BRE1
• Gene Symbols: RNF20
• Host Species: Rabbit
• Immunogen: Between 125 and 175
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 109331, 56254
• Target Species: Human, Mouse
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG