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Invitrogen™ RNF216 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520079

Catalog No. PIPA520079


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Description

Description

A suggested positive control is mouse heart tissue lysate. PA5-20079 can be used with blocking peptide PEP-0197.

Activation of NF-κB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88. Several regulatory mechanisms exist to control TLR signal transduction, including the inhibition of TLR expression and signaling by molecules such as ST2 and SIGIRR. Another mechanism is by the ubi-quitinization of selected TLRs by TRIAD3A, an E3 ubiquitin-protein ligase. TRIAD3A is a RING finger protein that can bind to TLR4 and TLR9, and to a lesser extent TLR3 and TLR5, catalyzing the ubiquitization of these molecules. Overexpression of TRIAD3A promoted the nearly complete degradation of TLR4 and TLR9; this reduction was reflected in the decreased signal-specific activation by ligands specific for these TLRs. Conversely, depletion of TRIAD3A resulted in enhanced TLR activation.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

RNF216
Polyclonal
Unconjugated
RNF216
2810055G22Rik; AI647468; AU019462; C86502; CAHH; E3 ubiquitin ligase; E3 ubiquitin-protein ligase RNF216; F830018F18Rik; RGD1565135; RING finger protein 216; RING-type E3 ubiquitin transferase RNF216; RNF216; Triad domain-containing protein 3; TRIAD3; triad3a; U7I1; UBCE7IP1; UbcM4-interacting protein 83; ubiquitin-conjugating enzyme 7-interacting protein 1; Uip83; Zin; zinc finger protein inhibiting NF-kappa-B
Rabbit
Ion-exchange chromatography
RUO
108086, 54476
Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Liquid
Immunohistochemistry, Western Blot, Immunocytochemistry
1 mg/mL
PBS with 0.02% sodium azide
P58283, Q9NWF9
RNF216
A peptide corresponding to 15 amino acids near the amino-terminus of mouse TRIAD3A.
100 μg
Primary
Human, Mouse
Antibody
IgG
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