Invitrogen™ RNF3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5113596

Catalog No. PIPA5113596

Description

Immunogen sequence: FYHKLGMEVP GDIKGETCSA KQHLDSHRNG ETKADDSSNK EAAEEKPEED For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. Predicted homology: Cow: 93%; Dog: 93%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 86%; Pig: 100%; Rabbit: 86%; Rat: 86%.

Phosphorylase kinase is a hexadecameric enzyme that is comprised of four copies of four subunits that are encoded by four separate genes: PHKA, PHKB, PHKG, and PH kDa. This serine/threonine specific kinase converts glycogen phosphorylase b to glycogen phosphorylase a, resulting in the release of glucose-1-phophate from glycogen. PHKB (Phosphorylase b kinase regulatory subunit beta) is a 1093 amino acid subunit of phosphorylase kinase that, along with PHKA, has regulatory functions controlled by phosphorylation. Defects in the gene encoding PHKB are the cause of glycogen storage disease type 9B, which is also known as phosphorylase kinase deficiency of liver and muscle. This disease is characterized by a mild phenotype of hepatomegaly with only slightly elevated transaminase and plasma lipids, no clinical muscle involvement, and generally is correlated with a gradual improvement with increasing age. There are four isoforms of PHKB that are produced as a result of alternative splicing events.

Specifications

• Antigen: RNF3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PCGF3
• Gene Alias: 2310035N15Rik; AI662857; D630042K08Rik; D6S113E; DADB-17J1.3; DKFZp686D20235; DKFZp686N0336; DONG1; E430039C14; FLJ31942; FLJ36550; FLJ43813; FSH; FSRG1; KIAA9001; MGC129075 protein; MGC129615; MGC40413; NAT; PCGF3; polycomb group ring finger 3; polycomb group RING finger protein 3; ring finger protein 3; RING finger protein 3A; RING3; RNF3; RNF3A
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10336
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q3KNV8
• Gene Symbols: PCGF3
• Immunogen: Synthetic peptide directed towards the middle region of human PCGF3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG