Invitrogen™ RNF3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596686

Catalog No. PIPA596686

Description

Immunogen sequence: MLTRKIKLWD INAHITCRLC SGYLIDATTV TECLHTFCRS CLVKYLEENN TCPTCRIVIH QSHPLQYIGH DRTMQDIVYK LVPGLQEAEM RKQREFYHKL GMEVPGDIKG ETCSAKQHLD SHRNGETKAD DSSNKEAAEE KPEEDNDYHR SDEQVSICLE CNSSKLRGLK RKWIRCSAQA TVLHLKKFIA KKLNLSSFNE LDILCNEEIL GKDHTLKFVV VTRWRFKKAP LLLHYRPKMD LL; Positive Samples: Mouse kidney, Mouse heart; Cellular Location: Nucleus.

Phosphorylase kinase is a hexadecameric enzyme that is comprised of four copies of four subunits that are encoded by four separate genes: PHKA, PHKB, PHKG, and PH kDa. This serine/threonine specific kinase converts glycogen phosphorylase b to glycogen phosphorylase a, resulting in the release of glucose-1-phophate from glycogen. PHKB (Phosphorylase b kinase regulatory subunit beta) is a 1093 amino acid subunit of phosphorylase kinase that, along with PHKA, has regulatory functions controlled by phosphorylation. Defects in the gene encoding PHKB are the cause of glycogen storage disease type 9B, which is also known as phosphorylase kinase deficiency of liver and muscle. This disease is characterized by a mild phenotype of hepatomegaly with only slightly elevated transaminase and plasma lipids, no clinical muscle involvement, and generally is correlated with a gradual improvement with increasing age. There are four isoforms of PHKB that are produced as a result of alternative splicing events.

Specifications

• Antigen: RNF3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PCGF3
• Gene Alias: 2310035N15Rik; AI662857; D630042K08Rik; D6S113E; DADB-17J1.3; DKFZp686D20235; DKFZp686N0336; DONG1; E430039C14; FLJ31942; FLJ36550; FLJ43813; FSH; FSRG1; KIAA9001; MGC129075 protein; MGC129615; MGC40413; NAT; PCGF3; polycomb group ring finger 3; polycomb group RING finger protein 3; ring finger protein 3; RING finger protein 3A; RING3; RNF3; RNF3A
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 69587
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.8 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q8BTQ0
• Gene Symbols: PCGF3
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-242 of human PCGF3 (NP_0063062).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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