Invitrogen™ RNF34 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA597100

Catalog No. PIPA597100

Description

Immunogen sequence: MKAGATSMWA SCCGLLNEVM GTGAVRGQQS AFAGATGPFR FTPNPEFSTY PPAATEGPNI VCKACGLSFS VFRKKHVCCD CKKDFCSVCS VLQENLRRCS TCHLLQETAF QRPQLMRLKV KDLRQYLILR NIPIDTCREK EDLVDLVLCH HGLGSEDDMD TSSLNSSRSQ TSSFFTRSFF SNYTAPSATM SSFQGELMDG DQTSRSGVPA QVQSEITSAN; Positive Samples: U-251MG, LO2, HeLa, BT-474; Cellular Location: Cell membrane, Cytoplasm, Endomembrane system, Nucleus, Nucleus speckle, Peripheral membrane protein, cytosol.

The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Specifications

• Antigen: RNF34
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RNF34
• Gene Alias: AW061037; AW536122; BC004042; C88279; CARP1; CARP-1; Caspase regulator CARP1; caspases-8 and -10-associated RING finger protein 1; E3 ubiquitin-protein ligase RNF34; FLJ21786; FYVE-RING finger protein MOMO; hRFI; Human RING finger homologous to inhibitor of apoptosis protein; Momo; phafin 1; phafin-1; RFI; RIF; RIFF; ring finger protein 34; ring finger protein 34, E3 ubiquitin protein ligase; RING finger protein MOMO; RING finger protein RIFF; RING-type E3 ubiquitin transferase RNF34; RNF34
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 80196
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 0.62 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q969K3
• Gene Symbols: RNF34
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human RNF34 (NP_0794022).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG