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Invitrogen™ RNF41 Polyclonal Antibody
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Catalog No. PIPA530362
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100 μL
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PIPA530362 100 μL
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Catalog No. PIPA530362 Supplier Invitrogen™ Supplier No. PA530362
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431. Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (91%), Xenopus laevis (95%), Rhesus Monkey (100%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. Nrdp1, also known as RNF41 (RING finger protein 41), SBBI03 or FLRF, is a 317 amino acid protein that contains one RING-type zinc finger and one SIAH-type zinc finger. Expressed in testis, ovary and prostate, Nrdp1 functions as an E3 ubiquitin-protein ligase that, characteristic of E3 ligase proteins, accepts ubiquitin (in the form of a thioester) from an E2 ubiquitin-conjugating enzyme and transfers that ubiquitin residue to substrates targeted for degradation. Specifically, Nrdp1 interacts with ErbB-3 and UBPY, thereby targeting them for proteasomal degradation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RNF41
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.99 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene RNF41
Gene Accession No. Q9H4P4
Gene Alias 2210404G21Rik; 4930511A05Rik; 4933415P08Rik; D10Ertd722e; E3 ubiquitin-protein ligase NRDP1; fetal liver ring finger; FLRF; neuregulin receptor degradation protein-1; Nrdp1; RING finger protein 41; ring finger protein 41, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase NRDP1; Rnf41; SBBI03
Gene Symbols RNF41
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human RNF41. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10193
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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