Invitrogen™ RNF41 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA553495

Catalog No. PIPA553495

Description

Immunogen sequence: DAVLQAVIKR SLVESGCPAS IVNELIENAH ERSWPQGLAT LETRQMNRRY YENYVAKRIP GKQAVVVMAC ENQHMGDDMV QEPGLVMIFA HGVEEI Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. Nrdp1, also known as RNF41 (RING finger protein 41), SBBI03 or FLRF, is a 317 amino acid protein that contains one RING-type zinc finger and one SIAH-type zinc finger. Expressed in testis, ovary and prostate, Nrdp1 functions as an E3 ubiquitin-protein ligase that, characteristic of E3 ligase proteins, accepts ubiquitin (in the form of a thioester) from an E2 ubiquitin-conjugating enzyme and transfers that ubiquitin residue to substrates targeted for degradation. Specifically, Nrdp1 interacts with ErbB-3 and UBPY, thereby targeting them for proteasomal degradation.

Specifications

• Antigen: RNF41
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RNF41
• Gene Alias: 2210404G21Rik; 4930511A05Rik; 4933415P08Rik; D10Ertd722e; E3 ubiquitin-protein ligase NRDP1; fetal liver ring finger; FLRF; neuregulin receptor degradation protein-1; Nrdp1; RING finger protein 41; ring finger protein 41, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase NRDP1; Rnf41; SBBI03
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10193
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9H4P4
• Gene Symbols: RNF41
• Immunogen: Recombinant protein corresponding to Human RNF41. Recombinant protein control fragment (Product #RP-91674).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov