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  5. Tocris Bioscience™ RO-275

Tocris Bioscience™ RO-275
SDP

Catalog No. 897750 Shop All R&D Systems Products
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89-775-0 50 mg
89-771-0 10 mg
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Catalog No. 89-775-0 Supplier Tocris Bioscience™ Supplier No. 8977/50
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Description

Potent and selective HCN1 inhibitor

RO-275 is a potent and selective HCN1 (hyperpolarization-activated cyclic-nucleotide-gated channel 1) inhibitor (IC50 = 46 nM). It shows <100-fold selectivity over HCN2, HCN3 and HCN4. In vivo, RO-275 improves performance in a translationally relevant touchscreen task of working memory (TUNL) in rats. RO-275 is orally bioavailable and brain-penetrant.

Specifications

Chemical Name or Material 4-((2-Chloro-3-methylpyridin-4-yl)ethynyl)-5-methyl-1-(pyridin-3-yl)-1H-imidazole-2-carboxamide
CAS 2648837-04-9
Quantity 50 mg
Target Ion Channel Modulators
Molecular Formula C18H14ClN5O
Purity 98%
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