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  5. R&D Systems™ RO 4929097

R&D Systems™ RO 4929097
SDP

Catalog No. RD10193529 Shop All Novus Products
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RD10193529 10 mg
RD10193520 50 mg
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Catalog No. RD10193529 Supplier R&D Systems™ Supplier No. 8906/10

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Description

A Tocris product, part of R&D Systems.

RO 4929097 is a potent and selective γ-secretase inhibitor (IC50 = 4 nM), exhibiting over 100-fold selectivity against a panel of 75 different proteins. Inhibits cellular processing of Notch and Aβ40 (IC50 = 5 nM and 14 nM, respectively). In tumor cells, inhibition of Notch processing results in lowered expression of HES1. In multiple xenograft models, RO 4929097 displays antitumour effects with no associated body weight loss or Notch-related toxicities. In melanoma cell lines, it inhibits tumor formation and blocks invasive growth pattern of metastatic melanoma. Can also be used to induce differentiation of iEM cells into luminal cells. Orally bioavailable.

Specifications

Chemical Name or Material 2,2-Dimethyl-N-((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide
CAS 847925-91-1
Quantity 10 mg
Product Line Tocris
Target gamma-Secretase inhibitors
Molecular Formula C22H20F5N3O3
Purity 98%
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