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Tocris Bioscience™ Ro 5-3335
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Catalog No. 469410
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46-941-0 10mg
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Description

Core binding factor inhibitor; attenuates hematopoiesis

Ro 5-3335 is a core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Reduces leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. Also a Tat antagonist; inhibits HIV-1 replication in vitro.

Specifications

Quantity 10 mg
Product Type Ro 5-3335
Purity >98%
Molecular Weight (g/mol) 259.69
Inhibitors Ro 5-3335

For Research Use Only

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