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Tocris Bioscience™ Ro 61-8048
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Catalog No. 325450
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Catalog No. Quantity
32-545-0 50 mg
32-541-0 10 mg
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Description

Potent kynurenine 3-monooxygenase (KMO) inhibitor

Ro 61-8048 is a potent and competitive kynurenine 3-monooxygenase (kynurenine 3-hydroxylase; KMO) inhibitor (Ki = 4.8 nM, IC50 = 37 nM). Increases kynurenic acid levels to concentrations that antagonize the glycine site of NMDA receptors. Brain penetrant and exhibits antidystonic, anticonvulsant and neuroprotective activities. Ro 61-8048 decreases nicotine self-administration in vivo. Ro 61-8048 prevents post-operative brain edema and consequent neuronal apoptosis in a rat model of surgically induced brain injury.

Chemical Identifiers

CAS 199666-03-0
Molecular Formula C17H15N3O6S2

Specifications

Quantity 50 mg
Formula Weight 421.45
Purity >99%
Molecular Weight (g/mol) 421.442
Chemical Name or Material Ro 61-8048

Safety and Handling

Recommended Storage Store at +4°C
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