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ROC1 Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501565200
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50-156-5200 20 μL
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Catalog No. 50-156-5200 Supplier Bethyl Laboratories, Inc Supplier No. A303462AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

ROC1 and ROC2 are the two highly conserved RING finger proteins that are homologous to APC11, a subunit of the anaphase-promoting complex (APC). ROC1 and ROC2 commonly interact with all cullins while APC11 specifically interacts with APC2, a cullin-related APC subunit. ROC1 and APC11 immunocomplexes can catalyze isopeptide ligations to form polyubiquitin chains in an E1- and E2-dependent manner. ROC1 is thought to play a unique role in the ubiquitination reaction by heterodimerizing with cullin1 to catalyze ubiquitin polymerization.

Specifications

Antigen ROC1
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene RBX1
Gene Accession No. P62877, P62878
Gene Alias RING box protein 1, RING finger protein 75, RING-box protein 1, ZYP protein, regulator of cullins 1
Gene Symbols Rbx1
Host Species Rabbit
Immunogen Between 1 and 50
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56438, 9978
Target Species Human, Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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