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ROCK1 Mouse anti-Human, Mouse, Rat, Clone: 3G5E12, Proteintech
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Catalog No. 501737184 Shop All Proteintech Group Inc Products
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50-173-7184 150 μL
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Catalog No. 50-173-7184 Supplier Proteintech Group Inc Supplier No. 667821IG150UL
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Description

Mouse Monoclonal Antibody

The Rho target protein, Rho-associated coiled coil-containing protein kinase (ROCK)-1 has been found to be a new Caspase-3 substrate. ROCK, one of the effectors of the small GTPase Rho, has recently been shown to contribute significantly to myosin light chain (MLC) activation through two pathways: direct phosphorylation of MLC and phosphorylation of MLC phosphatase, leading to its inhibition. The increase in cellular contractility that is necessary for apoptotic membrane blebbing implies sustained augmentation of MLC phosphorylation. ROCK-1 consists of an amino-terminal kinase domain and an inhibitory cysteine/histidine-rich C-terminal domain that is located within a pleckstrin-homology region. They are joined by a variable region that contains the Rho-binding domain. During apoptosis, ROCK-I is cleaved by caspase-3 at a conserved DETD1113/G sequence and its carboxy-terminal inhibitory domain is removed, resulting in deregulated and constitutive kinase activity. The caspase-3-mediated cleavage and activation of ROCK I induces phosphorylation of MLC and membrane blebbing, one of the first events in the execution phase of apoptosis.

Specifications

Antigen ROCK1
Applications Western Blot
Classification Monoclonal
Clone 3G5E12
Concentration 0.8 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene ROCK1
Gene Accession No. P70335, Q13464, Q63644
Gene Alias p160 ROCK 1, P160ROCK, PRO0435, ROCK1
Gene Symbols ROCK1
Host Species Mouse
Immunogen ROCK1 Fusion Protein Ag16317
Purification Method Protein G
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19877, 6093, 81762
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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