ROCK1 Mouse anti-Human, Mouse, Rat, Clone: GT464, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527779
Positive Control: 293T, HeLa, HepG2, Neuro2A, GL261, NIH-3T3, BCL-1, Raw264.7, C2C12, PC-12, Rat2, PC-12 (30uM cisplatin for 24hr) Predicted Reactivity: Zebrafish (90%), Rabbit (98%), Chicken (96%), Rhesus Monkey (98%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.ROCK1 encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
|PBS with no preservative|
|P70335, Q13464, Q63644|
|P160ROCK, Rho-associated, coiled-coil containing protein kinase 1, ROCK-I|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|19877, 6093, 81762|
|Recombit protein encompassing a sequence within the N-terminus region of human ROCK1. The exact sequence is proprietary.|
|Human, Mouse, Rat|
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