Invitrogen™ ROCK2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596400

Catalog No. PIPA596400

Description

Immunogen sequence: LDSKDSDIEQ LRSQLQALHI GLDSSSIGSG PGDAEADDGF PESRLEGWLS LPVRNNTKKF GWVKKYVIVS SKKILFYDSE QDKEQSNPYM VLDIDKLFHV RPVTQTDVYR ADAKEIPRIF QILYANEGES KKEQEFPVEP VGEKSNYICH KGHEFIPTLY HFPTNCEACM KPLWHMFKPP PALECRRCHI KCHKDHMDKK EEIIAPCKVY YDISTAKNLL LLANSTEEQQ KWVSRLVKKI PKKPPAPDPF ARSSPRTSMK IQQNQSIRRP SRQLAPNKPS; Positive Samples: HepG2, HT-29, ES-2, U-937, U-87MG, Mouse lung, Mouse heart; Cellular Location: Cell membrane, Cytoplasm, Nucleus, Peripheral membrane protein, centrosome, cytoskeleton, microtubule organizing center.

ROCK2, the predominant ROCK isoform in skeletal muscle, is an important regulator downstream of Rho GTPases. ROCK2 regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

Specifications

• Antigen: ROCK2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ROCK2
• Gene Alias: B230113H15Rik; KIAA0619; mKIAA0619; p150 ROK-alpha; p164 ROCK-2; Rho associated coiled-coil containing protein kinase 2; Rho kinase 2; RhoA - binding serine/threosine kinase alpha (ROK - alpha); rhoA-binding kinase 2; Rho-associated coiled-coil containing protein kinase 2; Rho-associated coiled-coil forming kinage 2; Rho-associated coiled-coil forming kinase 2; rho-associated protein kinase 2; Rho-associated, coiled-coil-containing protein kinase 2; rho-associated, coiled-coil-containing protein kinase II; Rho-kinase; ROCK II; Rock2; Rock2m; rockii; ROCK-II; ROK; ROKalpha
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19878, 25537, 9475
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.92 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O75116, P70336, Q62868
• Gene Symbols: ROCK2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1109-1388 of human ROCK2 (NP_0048412).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG