Invitrogen™ RON Monoclonal Antibody (CL0463)

Catalog No.	Quantity
PIMA531354	100 μL

Catalog No. PIMA531354 Supplier Invitrogen™ Supplier No. MA531354

Description

Mouse Monoclonal Antibody

Immunogen sequence: EDPVVLSISP NCGYINSHIT ICGQHLTSAW HLVLSFHDGL RAVESRCERQ LPEQQLCRLP EYVVRDPQGW VAGNLSARGD GAAGFTLPGF RFLPPPHPPS ANLVPLKP Highest antigen sequence indentity to the following orthologs: Mouse - 74%, Rat - 69%.

MST1R (RON) is a receptor tyrosine kinase involved in cell proliferation and motility. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. MST1R/Ron expression has been documented in many normal human tissues. ESTs have been isolated from several tissue libraries, including normal colon, mouth, prostate, and testis and cancerous colon, prostate, stomach, and uteru.

Specifications

• Antigen: RON
• Applications: Western Blot
• Classification: Monoclonal
• Clone: CL0463
• Concentration: 0.7 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: MST1R
• Gene Accession No.: Q04912
• Gene Alias: CD136; Cdw136; c-met-related tyrosine kinase; friend virus susceptibility 2; Fv2; Fv-2; macrophage stimulating 1 receptor; macrophage stimulating 1 receptor (c-met-related tyrosine kinase); macrophage-stimulating protein receptor; Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain; MSP receptor; Mst1r; MST1R variant RON30; MST1R variant RON62; p185-Ron; protein tyrosine kinase 8; Protein-tyrosine kinase 8; PTK8; PTK8 protein tyrosine kinase 8; receptor protein tyrosine kinase, c-met-related; RON; RON variant E2E3; Stem cell-derived tyrosine kinase; STK
• Gene Symbols: MST1R
• Host Species: Mouse
• Immunogen: Recombinant protein fragment of Human MST1R (Product #RP-89803)
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4486
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1