Invitrogen™ ROR1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596241

Catalog No. PIPA596241

Description

Positive Samples: A-549, 293T, HT-29, SKOV3; Cellular Location: Membrane, Single-pass type I membrane protein Immunogen sequence: ARGAAAQETE LSVSAELVPT SSWNISSELN KDSYLTLDEP MNNITTSLGQ TAELHCKVSG NPPPTIRWFK NDAPVVQEPR RLSFRSTIYG SRLRIRNLDT TDTGYFQCVA TNGKEVVSST GVLFVKFGPP PTASPGYSDE YEEDGFCQPY RGIACARFIG NRTVYMESLH MQGEIENQIT AAFTMIGTSS HLSDKCSQFA IPSLCHYAFP YCDETSSVPK PRDLCRDECE ILENVLCQTE YIFARSNPMI LMRLKLPNCE DLPQPESPEA ANCIRIGIPM ADPINKNHKC YNSTGVDYRG TVSVTKSGRQ CQPWNSQYPH THTFTALRFP ELNGGHSYCR NPGNQKEAPW CFTLDENFKS DLCDIPACDS KDSKEKNKME.

Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated, surface protein predominantly expressed during embryogenesis, where it is involved in organ morphogenesis, nervous system development, and neural progenitor cell maintenance and survival. Virtually absent from normal pediatric and adult tissues, with the exception of low-level expression in a subset of immature b cell precursors known as hematogones and adipocytes, ROR1 is notably overexpressed, and considered a survival factor, in a number of B lymphoid and epithelial malignancies: including chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), marginal zone lymphoma, lung adenocarcinoma. First identified during PCR-based cloning of a human neuroblastoma cell line in search of tyrosine kinases similar to tropomyosin-receptor-kinase (Trk) neurotropic receptors, ROR1, along with the related receptor tyrosine kinase (RTK) ROR2, was catalogued as an orphan receptor due to the fact its related ligand remained elusive. Wnt-5a has since been suggested as a candidate ligand for ROR1, and ROR1 has been implicated to function as a pseudokinase, promoting proliferation and resistance to apoptosis in cancer cells through interaction with Wnt-5a, and TCL1-co-activation of AKT. ROR1 is expressed as a glycoprotein containing extracellular immunoglobulin (Ig)-like, Frizzled, and Kringle domains, as well as an intracellular region containing a tyrosine kinase domain.

Specifications

• Antigen: ROR1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ROR1
• Gene Alias: 2810404D04Rik; dJ537F10.1; Inactive tyrosine-protein kinase transmembrane receptor ROR1; MGC99659; mRor1; neurotrophic tyrosine kinase, receptor related 1; neurotrophic tyrosine kinase, receptor-related 1; Ntrkr1; receptor tyrosine kinase like orphan receptor 1; receptor tyrosine kinase-like orphan receptor 1; RGD1559469; ROR1; T-ROR1; tyrosine-protein kinase transmembrane receptor ROR1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4919
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.03 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: Q01973
• Gene Symbols: ROR1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 24-403 of human ROR1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov