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ROR2 Mouse anti-Human, Clone: OTI3H3, liquid, TrueMAB™
SDP

Catalog No. 501683152
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50-168-3152 100 μL
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Catalog No. 50-168-3152 Supplier OriGene Supplier No. TA810008
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Description

Mouse Monoclonal Antibody

ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1). BDB1 is an autosomal domit skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Defects in ROR2 are a cause of recessive Robinow syndrome (RRS). RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.

Specifications

Antigen ROR2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI3H3
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene ROR2
Gene Accession No. Q01974
Gene Alias BDB, BDB1, NTRKR2
Gene Symbols ROR2
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 796-927 of human ROR2 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4920
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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