RORA Monoclonal Antibody (OTI2E8), TrueMAB™, OriGene

Catalog No.	Quantity
50-167-9623	100 μL

Catalog No. 50-167-9623 Supplier OriGene Supplier No. TA803200

Description

Mouse Monoclonal Antibody

RORA is a receptor for retinoic acid belonging to the NR1 subfamily of nuclear hormone receptors with a nuclear receptor DNA binding domain. RORA binds either as a monomer or as a homodimer to the retinoic acid response element and thus regulates gene expression and also controls cell function. Though the exact function of RORA is yet unknown, it interacts with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, NM23-1, the product of a tumor metastasis suppressor candidate gene, CDK7, NCOA3 and NCOA6 coactivators. It is found to express in mesenchymal stem cells derived from bone marrow and are known to act by direct modulation of a bone matrix component. It is widely expressed in most of the tissues. Chromosomal aberrations involving RORA may be a cause of acute promyelocytic leukemia (APL).

Specifications

• Antigen: RORA
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI2E8
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: RORA
• Gene Accession No.: P35398
• Gene Alias: NR1F1, ROR1, ROR2, ROR3, RZR-ALPHA, RZRA
• Gene Symbols: RORA
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 98-345 of human RORA produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6095
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a