Invitrogen™ RORA Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA1812

Catalog No. PA1812

Description

PA1-812 detects human ROR alpha protein in transfected cell samples. PA1-812 is specific for alpha isotypes. PA1-812 has successfully been used in Western blot procedures. By Western blot, this antibody detects an ~56 kDa protein representing ROR alpha in transfected BL21 cells using a pGEX-hROR alpha1-GST vector. The PA1-812 immunogen is a synthetic peptide corresponding to residues K(541) E L F T S E F E P A M Q I D G(556) of human ROR alpha. This peptide (Cat. # PEP-230) is available for use in neutralization and control experiments.

RORA is a receptor for retinoic acid belonging to the NR1 subfamily of nuclear hormone receptors with a nuclear receptor DNA binding domain. RORA binds either as a monomer or as a homodimer to the retinoic acid response element and thus regulates gene expression and also controls cell function. Though the exact function of RORA is yet unknown, it interacts with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, NM23-1, the product of a tumor metastasis suppressor candidate gene, CDK7, NCOA3 and NCOA6 coactivators. It is found to express in mesenchymal stem cells derived from bone marrow and are known to act by direct modulation of a bone matrix component. It is widely expressed in most of the tissues. Chromosomal aberrations involving RORA may be a cause of acute promyelocytic leukemia (APL).

Specifications

• Antigen: RORA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RORA
• Gene Alias: 9530021D13Rik; nmf267; NR1F1; Nuclear receptor ROR-alpha; nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR related orphan receptor A; RAR-related orphan receptor A; RAR-related orphan receptor alpha; retinoic acid receptor-related orphan receptor alpha; retinoid-related orphan receptor alpha; retinoid-related orphan receptor-alpha; ROR Alpha; ROR1; ROR2; ROR3; Rora; Roralpha; ROR-alpha; RORalpha1; RZRA; RZR-ALPHA; sg; staggerer; thyroid hormone nuclear receptor alpha variant 4; tmgc26; transcription factor RZR-alpha
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 300807, 6095
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: P35398
• Gene Symbols: RORA
• Immunogen: Synthetic peptide corresponding to residues K(541) E L F T S E F E P A M Q I D G(556) of human ROR alpha.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov