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Invitrogen™ RORA Polyclonal Antibody
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Catalog No. PIPA585069
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100 μL
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PIPA585069 100 μL
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Catalog No. PIPA585069 Supplier Invitrogen™ Supplier No. PA585069
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Description

Rabbit Polyclonal Antibody

Keep as concentrated solution. Predicted reactivity: Mouse (100%), Rat (100%), Xenopus Tropicalis (100%), Bovine (100%). Positive Control: HeLa, HepG2, Molt-4, mouse brain, NIH-3T3. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

RORA is a receptor for retinoic acid belonging to the NR1 subfamily of nuclear hormone receptors with a nuclear receptor DNA binding domain. RORA binds either as a monomer or as a homodimer to the retinoic acid response element and thus regulates gene expression and also controls cell function. Though the exact function of RORA is yet unknown, it interacts with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, NM23-1, the product of a tumor metastasis suppressor candidate gene, CDK7, NCOA3 and NCOA6 coactivators. It is found to express in mesenchymal stem cells derived from bone marrow and are known to act by direct modulation of a bone matrix component. It is widely expressed in most of the tissues. Chromosomal aberrations involving RORA may be a cause of acute promyelocytic leukemia (APL).
TRUSTED_SUSTAINABILITY

Specifications

Antigen RORA
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.01% thimerosal; pH 7
Gene RORA
Gene Accession No. P35398, P51448
Gene Alias 9530021D13Rik; nmf267; NR1F1; Nuclear receptor ROR-alpha; nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR related orphan receptor A; RAR-related orphan receptor A; RAR-related orphan receptor alpha; retinoic acid receptor-related orphan receptor alpha; retinoid-related orphan receptor alpha; retinoid-related orphan receptor-alpha; ROR Alpha; ROR1; ROR2; ROR3; Rora; Roralpha; ROR-alpha; RORalpha1; RZRA; RZR-ALPHA; sg; staggerer; thyroid hormone nuclear receptor alpha variant 4; tmgc26; transcription factor RZR-alpha
Gene Symbols RORA
Host Species Rabbit
Immunogen Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human ROR alpha. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19883, 6095
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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