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Invitrogen™ RORB Polyclonal Antibody
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Catalog No. PIPA528742
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100 μL
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PIPA528742 100 μL
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Catalog No. PIPA528742 Supplier Invitrogen™ Supplier No. PA528742
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: HeLa, HepG2, Molt-4, mouse brain. Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (100%), Chicken (100%), Sheep (100%), Rhesus Monkey (100%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Retinoid-related orphan receptor beta (ROR beta), a NR1 thyroid hormone receptor, affects the development and functioning of the central nervous system, including sensory input integration and circadian timing. Disruption of ROR beta in mice results in juvenile ataxia, retinal degeneration, circadian activity abnormalities, and delayed onset of male fertility. ROR beta binds to the monomeric response elements containing the sequence AnnTAGGTCA as a monomer. An alternatively spliced isoform, ROR beta2, has been isolated from rats, and the expression of ROR beta2 is confined to the pineal gland and retina. ROR beta2 shares common DNA- and putative ligand-binding domains with wild-type ROR beta but is characterized by a different amino-terminal domain. ROR beta expression has been documented in various regions of the mouse brain.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RORB
Applications Immunohistochemistry (Frozen), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene RORB
Gene Accession No. Q8R1B8, Q92753
Gene Alias bA133M9.1; Nr1f2; Nuclear receptor ROR-beta; nuclear receptor RZR-beta; Nuclear receptor subfamily 1 group F member 2; RAR related orphan receptor B; RAR-related orphan receptor B; RAR-related orphan receptor beta; retinoic acid-binding receptor beta; retinoid-related orphan receptor b; retinoid-related orphan receptor beta; retinoid-related orphan receptor-beta; ror beta; Rorb; Rorbeta; ROR-BETA; rzrb; RZR-beta; sb:eu943; transcription factor; Unknown (protein for IMAGE:7173671)
Gene Symbols RORB
Host Species Rabbit
Immunogen Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human ROR beta. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 225998, 6096
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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