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Invitrogen™ ROS1 Polyclonal Antibody

Catalog No. PIPA130318
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400 μL
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PIPA130318 400 μL
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Catalog No. PIPA130318 Supplier Invitrogen™ Supplier No. PA130318

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

Description

Rabbit Polyclonal Antibody

HL-60 cell lysate may be used as a positive control for this product. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

ROS1 is a tyrosine kinase that functions as a growth or differentiation factor receptor. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
TRUSTED_SUSTAINABILITY

Specifications

Antigen ROS1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.79 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide
Gene ROS1
Gene Accession No. P08922
Gene Alias c-ros; c-ros oncogene 1 , receptor tyrosine kinase; c-Ros receptor tyrosine kinase; c-ros-1; heart - derived c - ros - 1 proto - oncogene; MCF3; Proto-oncogene c-Ros; proto-oncogene c-Ros-1; Proto-oncogene tyrosine-protein kinase ROS; receptor tyrosine kinase c-ros oncogene 1; ROS; ROS proto-oncogene 1 , receptor tyrosine kinase; ROS proto-oncogene 1, receptor tyrosine kinase; Ros1; Ros-1; Ros1 proto-oncogene; ROS1C; RP1-179P9.1; transmembrane tyrosine-specific protein kinase; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homolog 1
Gene Symbols ROS1
Host Species Rabbit
Immunogen Synthetic peptide conjugated to KLH, corresponding to amino acids 39-57 of Human ROS.
Purification Method Protein G
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6098
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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