Invitrogen™ RPL36 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5117106

Catalog No. PIPA5117106

Description

Positive Samples: PC-12, HepG2, Jurkat, HeLa, Mouse spleen, Mouse lung, Rat spleen, Rat lung Immunogen sequence: MALRYPMAVG LNKGHKVTKN VSKPRHSRRR GRLTKHTKFV RDMIREVCGF APYERRAMEL LKVSKDKRAL KFIKKRVGTH IRAKRKREEL SNVLAAMRKA AAKKD.

The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.

Specifications

• Antigen: RPL36
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Rpl36
• Gene Alias: 60S ribosomal protein L36; L36; Large ribosomal subunit protein eL36; ribosomal protein L36; RPL36
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 25873, 54217, 58927
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.89 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P39032, P47964, Q9Y3U8
• Gene Symbols: Rpl36
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-105 of human RPL36 (NP_0562292).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov