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Invitrogen™ RPL7A Polyclonal Antibody
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Catalog No. PIPA5103550
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PIPA5103550 100 μL
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Catalog No. PIPA5103550 Supplier Invitrogen™ Supplier No. PA5103550
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total RPL7A.

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RPL7A
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Rpl7a
Gene Accession No. P12970, P62424, P62425
Gene Alias 60S ribosomal protein L7a; L7A; Large ribosomal subunit protein eL8; PLA-X polypeptide; ribosomal protein L7a; RPL7A; Surf3; SURF-3; surfeit 3; surfeit locus protein 3; thyroid hormone receptor uncoupling protein; TRUP
Gene Symbols Rpl7a
Host Species Rabbit
Immunogen A synthesized peptide derived from human RPL7A(Accession P62424), corresponding to amino acid residues P16-Q66.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27176, 296596, 6130
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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