Invitrogen™ RPL7A Recombinant Rabbit Monoclonal Antibody (4I8Y6)

Catalog No.	Quantity
PIMA537881	100 μL

Catalog No. PIMA537881 Supplier Invitrogen™ Supplier No. MA537881

Description

Rabbit Recombinant Monoclonal Antibody

Positive Samples: 293T, PC-12, HepG2, NIH/3T3, Raji, Mouse lung, Mouse liver, Rat lung, Rat liver Immunogen sequence: MPKGKKAKGK KVAPAPAVVK KQEAKKVVNP LFEKRPKNFG IGQDIQPKRD LTRFVKWPRY IRLQRQRAIL YKRLKVPPAI NQFTQALDRQ TATQLLKLAH KYRPETKQEK KQRLLARAEK KAAGKGDVPT KRPPVLRAGV NTVTTLVENK KAQLVVIAHD VDPIE.

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Specifications

• Antigen: RPL7A
• Applications: ELISA, Western Blot
• Classification: Recombinant Monoclonal
• Clone: 4I8Y6
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: Rpl7a
• Gene Accession No.: P12970, P62424, P62425
• Gene Alias: 60S ribosomal protein L7a; L7A; Large ribosomal subunit protein eL8; PLA-X polypeptide; ribosomal protein L7a; RPL7A; Surf3; SURF-3; surfeit 3; surfeit locus protein 3; thyroid hormone receptor uncoupling protein; TRUP
• Gene Symbols: Rpl7a
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-165 of human RPL7A (P62424).
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 27176, 296596, 6130
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG