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Invitrogen™ RPRD1B Polyclonal Antibody
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Catalog No. PIPA531614
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100 μL
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PIPA531614 100 μL
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Catalog No. PIPA531614 Supplier Invitrogen™ Supplier No. PA531614
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, HeLa, HepG2. Predicted reactivity: Mouse (98%), Rat (98%), Xenopus laevis (83%), Chicken (93%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen RPRD1B
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.01% thimerosal; pH 7
Gene RPRD1B
Gene Accession No. Q9CSU0, Q9NQG5
Gene Alias 2610304G08Rik; 2810446G03Rik; C20orf77; Cell cycle-related and expression-elevated protein in tumor; cell-cycle related and expression-elevated protein in tumor; CREPT; dJ1057B20.2; NET60; regulation of nuclear pre-mRNA domain containing 1B; regulation of nuclear pre-mRNA domain-containing protein 1B; RGD1304782; Rprd1b
Gene Symbols RPRD1B
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human RPRD1B. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 58490, 70470
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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