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RPS24 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group Inc 148311AP150UL

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Catalog No. 50-172-9761


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Description

Description

Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintece. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at ′Ser-62′ and ′Ser-67′, respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. Ota T., Nat. Genet. 36:40-45(2004). Deloukas P., Nature 429:375-381(2004). Beausoleil S.A., Nat. Biotechnol. 24:1285-1292(2006).
Specifications

Specifications

RPS24
Polyclonal
Unconjugated
RPS24
40S ribosomal protein S24, DBA3, ribosomal protein S24, RPS24
Rabbit
Antigen Affinity Chromatography
RUO
20088, 6229, 81776
-20°C
Liquid
Immunocytochemistry, Immunofluorescence, Western Blot
0.18 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P62847, P62849, P62850
RPS24
RPS24 Fusion Protein Ag6621
150 μL
Primary
Human, Mouse, Rat
Antibody
IgG
SDS
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Product Certifications
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