RPS6KB1 Mouse anti-Canine, Human, Mouse, Clone: OTI6B2, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF502929

Catalog No. 50-166-1743

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The p70 S6 kinase (p70 Ribosomal Protein S6 Kinase, p70S6K) is a 70 kDa member of the ribosomal S6 kinase (RSK) family of serine/threonine kinases. p70 S6 kinase is predomitly localized in the cytoplasm, and is essential in growth factors regulated cell proliferation, pathways involving cell motility, such as metastases, the immune response, and tissue repair. p70 S6 kinase acts downstream of phosphoinositide (PI) 3-kinase, and its main physiological target is the S6 ribosomal protein, which is involved in upregulation of protein synthesis. The kinase activity of p70 S6 kinase leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding p70 S6 kinase and overexpression are seen in some breast cancer cell lines.

Specifications

• Antigen: RPS6KB1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: RPS6KB1
• Gene Alias: PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70 S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 480580, 6198, 72508
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI6B2
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P23443, Q8BSK8
• Gene Symbols: RPS6KB1
• Immunogen: Full length human recombit protein of human RPS6KB1 produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Canine, Human, Mouse
• Product Type: Antibody
• Isotype: IgG1