Invitrogen™ RPSA Monoclonal Antibody (RP-01), Alexa Fluor™ 488

Catalog No.	Quantity
PIMA544138	100 μg

Catalog No. PIMA544138 Supplier Invitrogen™ Supplier No. MA544138

Description

Mouse Monoclonal Antibody

This antibody recognizes ribosomal protein SA (RPSA), which is important for formation and stability of 40S ribosomal subunit, and is overexpressed in many carcinomas.

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Specifications

• Antigen: RPSA
• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: RP-01
• Concentration: 0.1 mg/mL
• Conjugate: Alexa Fluor 488
• Formulation: PBS with 0.2% BSA and 15mM sodium azide
• Gene: RPSA
• Gene Accession No.: P08865, P14206, P26452, P50890, Q3ZM03
• Gene Alias: 37 kDa laminin receptor; 37 kDa laminin receptor precursor; 37 kDa laminin receptor precursor {ECO:0000255; 37 kDa oncofetal antigen; 37/67 kDa laminin receptor; 37/67 kDa laminin receptor {ECO:0000255; 37LRP; 37LRP {ECO:0000255; 40S ribosomal protein SA; 40S ribosomal protein SA {ECO:0000255; 67 kDa laminin receptor; 67 kDa laminin receptor {ECO:0000255; 67kDa; 67LR; 67LR {ECO:0000255; AL022858; colon carcinoma laminin-binding protein; HAMAP-Rule:MF_03016}; ICAS; LAMBR; Laminin receptor 1; laminin receptor 1 (67kD, ribosomal protein SA); laminin receptor 1 (ribosomal protein SA); laminin receptor 1 {ECO:0000255; laminin-binding protein precursor p40; laminin-binding protein precursor p40 {ECO:0000255; LamR; lamR {ECO:0000255; LAMR1; Lamrl1; LBP; LBP/p40; LBP/p40 {ECO:0000255; LRP; LRP/LR; LRP/LR {ECO:0000255; MLR; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4; OFA/iLRP; p40; P40-3; P40-3, functional; P40-8; P40-8, functional; ribosomal protein SA; Rpsa; rssa; SA; Small ribosomal subunit protein uS2
• Gene Symbols: RPSA
• Host Species: Mouse
• Immunogen: REPRLLVVTDPRADHQP.
• Purification Method: Size-exclusion chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 16785, 281898, 3921, 395181, 733335
• Target Species: Human, Mouse, Bovine, Chicken, Frog
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov