Invitrogen™ RPSA Polyclonal Antibody

Catalog No.	Quantity
PIPA597177	100 μL

Catalog No. PIPA597177 Supplier Invitrogen™ Supplier No. PA597177

Description

Rabbit Polyclonal Antibody

Immunogen sequence: MSGALDVLQM KEEDVLKFLA AGTHLGGTNL DFQMEQYIYK RKSDGIYIIN LKRTWEKLLL AARAIVAIEN PADVSVISSR NTGQRAVLKF AAATGATPIA GRFTPGTFTN QIQAAFREPR LLVVTDPRAD HQPLTEASYV NLPTIALCNT DSPLRYVDIA IPCNNKGAHS VGLMWWMLAR EVLRMRGTIS REHPWEVMPD LYFYRDPEEI EKEEQAAAEK AVTKEEFQGE WTAPAPEFTA TQPEVADWSE GVQVPSVPIQ QFPTEDWSAQ PATEDWSAAP TAQATEWVGA TTDWS; Positive Samples: Mouse heart, Mouse kidney; Cellular Location: Cell membrane, Cytoplasm, Nucleus.

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Specifications

• Antigen: RPSA
• Applications: ELISA, Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1.33 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene: RPSA
• Gene Accession No.: P08865, P14206, P38983
• Gene Alias: 37 kDa laminin receptor; 37 kDa laminin receptor precursor; 37 kDa laminin receptor precursor {ECO:0000255; 37 kDa oncofetal antigen; 37/67 kDa laminin receptor; 37/67 kDa laminin receptor {ECO:0000255; 37LRP; 37LRP {ECO:0000255; 40S ribosomal protein SA; 40S ribosomal protein SA {ECO:0000255; 67 kDa laminin receptor; 67 kDa laminin receptor {ECO:0000255; 67kDa; 67LR; 67LR {ECO:0000255; AL022858; colon carcinoma laminin-binding protein; HAMAP-Rule:MF_03016}; ICAS; LAMBR; Laminin receptor 1; laminin receptor 1 (67kD, ribosomal protein SA); laminin receptor 1 (ribosomal protein SA); laminin receptor 1 {ECO:0000255; laminin-binding protein precursor p40; laminin-binding protein precursor p40 {ECO:0000255; LamR; lamR {ECO:0000255; LAMR1; Lamrl1; LBP; LBP/p40; LBP/p40 {ECO:0000255; LRP; LRP/LR; LRP/LR {ECO:0000255; MLR; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4; OFA/iLRP; p40; P40-3; P40-3, functional; P40-8; P40-8, functional; ribosomal protein SA; Rpsa; rssa; SA; Small ribosomal subunit protein uS2
• Gene Symbols: RPSA
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-295 of human 67kDa Laminin Receptor (NP_0022862).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 16785, 29236, 3921
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov