RRP8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-2719	Proteintech Group Inc 201291AP150UL	150 μL

Description

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at ′Lys-9′ (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.

Specifications

• Antigen: RRP8
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: O43159, Q5U4F0, Q9DB85
• Gene ID (Entrez): 101867, 23378, 308911
• Immunogen: RRP8 Fusion Protein Ag13994
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: RRP8

• Concentration: 0.5 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: Cerebral protein 1, KIAA0409, Nucleomethylin, RRP8
• Gene Symbols: Rrp8
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody