Invitrogen™ RSK1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA590646

Catalog No. PIPA590646

Description

Immunogen sequence: LGILLYTMLA GYTPFANGPS DTPEEILTRI GSGKFTLSGG NWNTVSETAK DLVSKMLHVD PHQRLTAKQV LQHPWVTQKD KLPQSQLSHQ DLQLVKGAMA ATYSALNSSK PTPQLKPIES SILAQRRVRK LPSTTL; Positive Samples: HT-29, HeLa, MCF7, K-562, Mouse lung, Mouse brain; Cellular Location: Cytoplasm, Nucleus.

RPS6KA1 (RSK1) is a growth-factor regulated serine/threonine kinase that is involved in the MAPK cascade. It is thought to control cellular proliferation and differentiation through the phosphorylation of transcription factors. RPS6KA1 contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Specifications

• Antigen: RSK1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RPS6KA1
• Gene Alias: 90 kDa ribosomal protein S6 kinase 1; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1); hu-1; MAP kinase-activated protein kinase 1; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1; MAPK-activated protein kinase 1a; MAPKAP kinase 1; MAPKAP kinase 1a; MAPKAPK-1; mapkapk1a; MAPKAPK-1a; p90Rsk; P90-RSK; p90-RSK 1; p90Rsk1; p90-Rsk1; p90S6K; pp90RSK1; ribosomal protein S6 kinase 2 alpha; ribosomal protein S6 kinase 2 beta; ribosomal protein S6 kinase a, polypeptide 1; ribosomal protein S6 kinase A1; ribosomal protein S6 kinase A1 L homeolog; ribosomal protein S6 kinase alpha 1; Ribosomal protein S6 kinase alpha-1; Ribosomal protein S6 kinase II alpha; ribosomal protein S6 kinase II beta; ribosomal protein S6 kinase polypeptide 1; ribosomal protein S6 kinase, 90kD, polypeptide 1; Ribosomal protein S6 kinase, 90kD, 1; ribosomal protein S6 kinase, 90kDa, polypeptide 1; ribosomal protein S6 kinase, 90kDa, polypeptide 1 L homeolog; ribosomal protein S6 kinase, polypeptide A1; ribosomal S6 kinase 1; RPS6KA; Rps6ka1; rps6ka1.L; RPS6KA1L; rsk; RSK1; Rsk-1; S6 kinase II beta; S6 protein kinase (Rsk-1); S6K-alpha 1; S6K-alpha-1; S6KII-alpha; S6KII-beta; wu:fc56h07; XELAEV_18012109mg; zgc:152654
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20111, 6195, 81771
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.99 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P18653, Q15418, Q63531
• Gene Symbols: RPS6KA1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 600 to the C-terminus of human p90Rsk/RSK1/RPS6KA1 (NP_0029442).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov