Invitrogen™ RSPO2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA525188

Catalog No. PIPA525188

Description

This antibody is predicted to react with mouse based on sequence homology.

The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally-related, secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner that causes the stabilization, and resulting accumulation, of the intracellular signaling protein, beta-catenin. This activity effectively activates and increases the subsequent nuclear signaling of beta-catenin. R-Spondin can also bind to the previously discovered G-protein coupled receptors, LGR-4 and LGR-5. Rspo/beta-catenin signaling can act as an inducer of the transformed phenotype, and can also regulate the proliferation and differentiation of certain stem cell populations.

Specifications

• Antigen: RSPO2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RSPO2
• Gene Alias: 2610028F08Rik; AA673245; CRISTIN2; cristin-2; cysteine-rich and single thrombospondin domain-containing protein 2; D430027K22; ftls; hRspo2; mCristin-2; RGD1562331; Roof plate-specific spondin-2; Rspo2; R-spondin 2; R-spondin 2 homolog; R-spondin 2 homolog (Xenopus laevis); R-spondin-2; UNQ9384/PRO34209
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 340419
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.48 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q6UXX9
• Gene Symbols: RSPO2
• Immunogen: KLH conjugated synthetic peptide between 190-218 amino acids from the C-terminal region of human RSPO2.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov