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Invitrogen™ RSPO2 Polyclonal Antibody
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Catalog No. PIPA525188
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400 μL
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PIPA525188 400 μL
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Catalog No. PIPA525188 Supplier Invitrogen™ Supplier No. PA525188
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Description

Rabbit Polyclonal Antibody

This antibody is predicted to react with mouse based on sequence homology.

The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally-related, secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner that causes the stabilization, and resulting accumulation, of the intracellular signaling protein, beta-catenin. This activity effectively activates and increases the subsequent nuclear signaling of beta-catenin. R-Spondin can also bind to the previously discovered G-protein coupled receptors, LGR-4 and LGR-5. Rspo/beta-catenin signaling can act as an inducer of the transformed phenotype, and can also regulate the proliferation and differentiation of certain stem cell populations.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RSPO2
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.48 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene RSPO2
Gene Accession No. Q6UXX9
Gene Alias 2610028F08Rik; AA673245; CRISTIN2; cristin-2; cysteine-rich and single thrombospondin domain-containing protein 2; D430027K22; ftls; hRspo2; mCristin-2; RGD1562331; Roof plate-specific spondin-2; Rspo2; R-spondin 2; R-spondin 2 homolog; R-spondin 2 homolog (Xenopus laevis); R-spondin-2; UNQ9384/PRO34209
Gene Symbols RSPO2
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 190-218 amino acids from the C-terminal region of human RSPO2.
Purification Method Antigen affinity chromatography, Protein A
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 340419
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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