RTCA Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA539429

Catalog No. PIPA539429

Description

RTCD1 catalyzes the conversion of 3′-phosphate to a 2′,3′-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) the enzyme acts on RNA-N3′P to produce RNA-N3′PP5′A; (C) a non catalytic nucleophilic attack by the adjacent 2′hydroxyl on the phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. There are two named isoforms.

Specifications

• Antigen: RTCA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RTCA
• Gene Alias: RNA 3′-terminal phosphate cyclase, RNA cyclase, RNA-3′-phosphate cyclase, RNA terminal phosphate cyclase domain-containing protein 1, RTC domain-containing protein 1, RTCA, RPC, RPC1, RTC1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8634
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O00442
• Gene Symbols: RTCA
• Immunogen: A synthetic peptide derived from the internal region of human RTCD1
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov