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Invitrogen™ RTF1 Polyclonal Antibody
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Catalog No. PIPA5110333
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100 μL
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PIPA5110333 100 μL
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Catalog No. PIPA5110333 Supplier Invitrogen™ Supplier No. PA5110333
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LAKKQPLKTS EVYSDDEEEE EDDKSSEKSD RSSRTSSSDE EEEKEEIPPK SQPVSLPEEL NRVRLSRHKL ERWCHMPFFA KTVTGCFVRI GIGNHNSKPV Y.

Three isoforms of serine/threonine kinases, designated alphaPAK p68, betaPAK p65 and gammaPAK p62, have been shown to exhibit a high degree of sequence homology with the S. cerevisiae kinase Ste 20, involved in pheromone signaling. The alpha, beta and gammaPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. There are eight sites of autophosphorylation on gammaPAK, including Ser 19, Ser 141 and Thr 402, and phosphorylation of Ser 141 and Thr 402 is correlated with gammaPAK activation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RTF1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.57 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene RTF1
Gene Accession No. A2AQ19, Q92541
Gene Alias 2900005O08Rik; 6530416A09Rik; AI853581; AU043144; AW553985; cbp82; CG10955; CG10955-PA; CG10955-PB; Dmel\CG10955; Dmel_CG10955; dRtf1; gene trap locus 7; Gtl7; KIAA0252; ortholog of mouse gene trap locus 7; RNA polymerase-associated protein Rtf1; RNA polymerase-associated protein RTF1 homolog; Rtf1; RTF1 homolog, Paf1/RNA polymerase II complex component; Rtf1 Paf1/RNA polymerase II complex component homolog; Rtf1, Paf1/RNA polymerase II complex component, homolog; Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae); Rtf1-PA; Rtf1-PB
Gene Symbols RTF1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 300-400 of human RTF1 (NP_055953.3).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23168, 76246
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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